We investigated the association between hindfoot residual malalignment assessed on weightbearing computed tomography (WBCT) images and the development of periprosthetic cysts (PPCs) after total ankle replacement (TAR). We hypothesized that PPCs would be found predominantly medially in the varus configuration and laterally in the valgus configuration.

In this series, the PPC volume after primary TAR significantly correlated with postoperative hindfoot malalignment and longer follow-up.

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